Polygenic Risk Scores (PRS) can complement standard methods!
The MGZ - Munich offers Polygenic risk score analyses for the following diseases:
- Breast cancer
- Prostate cancer
- Fertility dysfunction
- Type 2 diabetes mellitus
- Coronary artery diseases
Despite major advances in diagnosis and therapy, cardiovascular diseases are the most common cause of death in Germany. Assessing the personal risk of coronary heart disease is the basis for preventive measures. Coronary heart disease (CHD) risk should be monitored over a lifetime because both CHD risk and CHD prevention are dynamic.
What is a Polygenic Risk Score?
To identify genetic risk factors, large collectives of unaffected individuals and individuals with coronary heart disease are compared in genome-wide association studies, with regard to millions of small differences within genomes known as SNPs (single-nucleotide polymorphisms). SNPs account for much of genome variability and underlie both disease-promoting and disease-protective factors. The effects of many disease-associated SNPs are assessed in bundles and individually combined into a polygenic risk score (PRS). Extensive studies have used PRS to successfully identify individuals with an increased risk of myocardial infarction (heart attacks).
Risk stratification by means of conventional risk factors (SCORE) in combination with polygenic risk scores (PRS) is designed to raise awareness of an individual’s risk for coronary heart disease and to provide motivation for heathy lifestyle choices.