Methylation analysis provides important information about the inactivation and regulation of DNA sections, associated with various disorders, which might go undetected when using only sequencing analyses or fragment length-based techniques.
The MGZ offers methylation analysis for the following syndromes and disorders:
|Beckwith-Wiedemann Syndrome (BWS)
Silver-Russell Syndrome (SRS/RSS)
|BWS/SRS Methylation Analysis|
|Temple Syndrome (Maternal UPD14) |
Kagami-Ogata Syndrome (Paternal UPD14)
|14q32||UPD14 Methylation Analysis|
|Angelman Syndrome (AS) Prader-Willi Syndrome (PWS)||15q11.2-q13||AS/PWS Methylation Analysis|
|Lynch Syndrome, Colorectal Cancer||MLH1 Promoter||MLH1 Promoter Analysis|
|X-Chromosome Inactivation||Xq12||X-Chromosome Inactivation Analysis|
Please note that these tests are currently available via Offline Ordering Only.
Click here for price and test ordering information.
We use one or more of the following methods for determining methylation status:
- Methylation-sensitive MLPA (MS-MLPA)
- Methylation-sensitive restriction analysis
Accepted Sample Types
- 2-4 mL EDTA blood
- 3-10 µg DNA
- 3-10 µg DNA (from tumor tissue – for MLH1 Promoter Analysis)
- 3-6 weeks
Price Inquiries & Test Ordering
To request price information:
- Request a cost statement by using our convenient contact form.
For detailed test ordering information:
- Please refer to the How to Order section of our website.
Questions? Contact us.
To view a sample report, click here.