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Methylation Analysis

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Methylation analysis provides important information about the inactivation and regulation of DNA sections, associated with various disorders, which might go undetected when using only sequencing analyses or fragment length-based techniques.

Tests Available

The MGZ offers methylation analysis for the following syndromes and disorders:

Phenotype Locus/Gene Product Name
Beckwith-Wiedemann Syndrome (BWS)
Silver-Russell Syndrome (SRS/RSS)
7p12, 7q32
BWS/SRS Methylation Analysis
Temple Syndrome (Maternal UPD14)
Kagami-Ogata Syndrome (Paternal UPD14)
14q32 UPD14 Methylation Analysis
Angelman Syndrome (AS) Prader-Willi Syndrome (PWS) 15q11.2-q13 AS/PWS Methylation Analysis
Lynch Syndrome, Colorectal Cancer MLH1 Promoter MLH1 Promoter Analysis
X-Chromosome Inactivation Xq12 X-Chromosome Inactivation Analysis

Please note that these tests are currently available via Offline Ordering Only.

Click here for price and test ordering information.


We use one or more of the following methods for determining methylation status:

  • Methylation-sensitive MLPA (MS-MLPA)
  • Methylation-sensitive restriction analysis

Sample Requirements

Accepted Sample Types

  • 2-4 mL EDTA blood
  • 3-10 µg DNA
  • 3-10 µg DNA (from tumor tissue – for MLH1 Promoter Analysis)

View all sample requirements

Turnaround Time

  • 3-6 weeks

Price Inquiries & Test Ordering

To request price information:

For detailed test ordering information:

Questions? Contact us.

Sample Reports

To view a sample report, click here.